Monday 7 January 2013

Intel announces new Lexington platform: up to 1.2 GHz, supports 1080p video and HSPA+ data speeds

Intel announces new Lexington platform: up to 1.2 GHz, supports 1080p video and HSPA+ data speeds

During Intel's press conference at CES 2013, the company outed a brand new platform for mobile devices known as Lexington (Z2420), intended mainly for devices headed to emerging markets. The Atom processor is optimized for Android apps and runs at up to 1.2 GHz with the company's hyper-threading technology. It supports dual 5- and 1.3-megapixel shooters with burst picture-taking at 7 fps, and it'll also decode and encode 1080p video at 30 fps; PowerVR's SGX 540 GPU will take care of graphics. The chip can deal with HSPA+ data speeds, microSD cards, dual SIMs (with dual standby), FM radio and WiDi streaming. It's already destined for handsets made by Acer, Safaricom and Lava.

Continue reading Intel announces new Lexington platform: up to 1.2 GHz, supports 1080p video and HSPA+ data speeds

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Source: http://www.engadget.com/2013/01/07/intel-announces-lexington-platform/

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Talks with government: TTP seeks military's ... - PKVIDS News

Spokesperson says political leadership in Pakistan ?has no powers?. ILLUSTRATION: JAMAL KHURSHID

ISLAMABAD:?

In the wake of the army?s new doctrine ? recognising homegrown militancy as the ?biggest threat? to national security ? the Tehreek-e-Taliban Pakistan (TTP) has decided to seek guarantees from the military for any peace dialogue with the government.

?Our central Shura (council) has unanimously decided to ask for the army?s guarantee for any talks with the government,? TTP spokesman Ehsanullah Ehsan told The Express Tribune by phone on Saturday.

He said the Taliban needed assurances from the security forces as the political leadership in Pakistan ?has no powers.?

?Although we have not yet received any response to our dialogue offer, our leadership still hopes for a positive response,? Ehsan said.

However, he ruled out any ceasefire with the government. ?Our war is based on Islamic ideology as Pakistan was also achieved on the slogan of Islam. We have no option but to fight for Islam. This is our obligation,? he said.

?The Taliban leadership is of the opinion that the army?s doctrine was aimed at us when they say that they face internal threat or threats from western borders and that is why we will look for the army?s assurance,? the TTP spokesman said.

Justice system

Asked about the credibility of the banned group?s justice system, Ehsan said the group had their own system and regularly sought advice from religious scholars.

?If they kill our people, if they kill our prisoners, our teachers and our children then they will face similar fate. We will react and it is a tradition in our society,? he said, adding that the group also punished its own people if found guilty. ?Recently, our religious scholars handed down death penalty to a TTP man and he was subsequently executed.?

Published in The Express Tribune, January 6th, 2013.

Article source: http://tribune.com.pk/story/489718/talks-with-government-ttp-seeks-militarys-guarantees/

Source: http://news.pkvids.com/2013/01/06/talks-with-government-ttp-seeks-militarys-guarantees/

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Exercise Focus: Bridges

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I?m often asked what?s a good exercise for the gluteus and hamstrings.? Bridges are one of the most underrated and underutilized exercises for working those muscles. The bridge is an excellent exercise to isolate and strengthen the gluteus, hamstrings, core stability muscles, hip/lower back as well as improve spinal stabilization. Most people do this exercise without added resistance, but that?s a mistake (see ?tip? below vid). Done with added resistance, there?s improved responses, as all muscles require added resistance (vs volume) to adapt and get stronger. And NO, they are not just for women!!! :)

Bridges are a highly functional exercise that can lead to both functional improvements as well as visual. For example, one practitioner of Brazilian?jiu jitsu I know said ?This is a key exercise for anyone who competes in?jiu jitsu tournaments. Strong bridge makes all the difference in escaping. I work bridges hard.?

Bridges are an exercise that have both expected and unexpected benefits both functionally (for various sports) and visually, for bodybuilders, figure/fitness, or the average person looking shape up and strengthen the area. It?s also used for both rehab and prehab. Personally, I tend to incorporate it into lower body days. A typical workout might look like: front squats, RDLs, Bridges, and planks, or a workout I did the other day geared more toward conditioning/GPP/conditioning was a complex of:

Sand bag step ups
Slayer Barbell Bridges
High/low Prowler sprints

Did three circuits? of the above then some planks and side planks. My butt was sore for days!

Tip: most people do bridges with body weight only as adding additional resistance comfortably is not always easy. The Slayer Barbell allows for as much added resistance as you could want in perfect comfort, which is one of many exercises this bar allows. If not using a Slayer, try putting a foam pad around an Olympic bar (so the bar does not dig into your hips), or try a plate across your lap, or a heavy medicine ball. None of those options are as comfortable and smooth as using the Slayer Barbell, but experiment with those options and see what works for you. As with any body weight only exercise, your own weight will only get you so far and added resistance will be needed for continued increases in strength, etc.

Note: if you want more information on Sandbags, Slayer Barbell, or Prowler sleds, go HERE and or use the search function (upper right hand corner of this site) to see more vids, articles, etc on them. They are ?must have? training tools in my book.

Source: http://www.brinkzone.com/general-fitness-info/exercise-focus-bridges/

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"General Hospi-Tale": Sung by The Afternoon Delights (1981) - From ...

For those of you who weren?t around in the early 1980s when daytime soaps were at their indisputable peak, The Afternoon Delights are ready to catch you up with their 1981 novelty song re-capping the happenings on the King of All Soaps, General Hospital.

My introduction to this show involved a pre-Robin Mattson Heather Webber dropping LSD into Diana Taylor?s iced tea as part of her plan to drive Diana to the mental ward and ?claim for her own Diana?s baby, who was actually Heather?s biological child sold months earlier on the black market. ?What Heather didn?t know was that the lazy susan the identical iced teas were sitting on was accidentally turned on when she wasn?t looking, and poor Heather ended up dosing herself. ?My mind exploded at the idea that this is what grown-ups got to do with their time. ?It explains a lot about my own personal life choices as an adult, but that?s a topic for another post.

The song chronicles the story lines happening in Port Charles post ?Luke Rapes Laura at the Campus Disco? and pre ?Remote Island Housing Evil Machine That Will Freeze the World? (as indicated by the line,?How it ends up nobody knows!?)

My favorite lyric in the song has to be??Alan was the father? of course. ?And he won?t give Monica? a divorce!? ?That?s followed closely by, ?Amy Vining likes to blab? Richard Simmons helps fight flab!?

The bad rap and the slutty horn section just add to the fun.

Click through to hear the song for yourself

general-hospi-tale.mp3

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Tags: Dr Noah Drake Rick Springfield, Freezing machine storyline General Hosptial, General Hospi-tale Afternoon Delights, General Hospital Afternoon Delights, General Hospital Novelty Song, General Hospital song 1981, Liz Taylor on General Hospital, Luke Spencer Tony Geary Genie Francis Laura Spencer, The Ice Princess storyline General Hospital

Posted in Uncategorized 2 hours ago at 3:19 pm. Add a comment

Source: http://tvfoodanddrink.com/2013/01/general-hospi-tale-afternoon-delights-1981/

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Sunday 6 January 2013

NY comptroller sues Qualcomm on political spending

(AP) ? New York's comptroller has sued Qualcomm Inc. in an attempt to compel the wireless technology company to disclose its political spending to him and other shareholders.

The lawsuit filed Wednesday in Delaware seeks a court order to inspect company records, saying prior requests for the information have been rebuffed by the San Diego-based corporation. The suit cites studies that say corporate political spending tends to hurt investor returns.

"We think the fullest possible disclosure is what we're entitled to as shareholders," Comptroller Thomas DiNapoli said. He is sole trustee of New York's pension fund for public workers, which has 6.1 million Qualcomm shares valued at almost $380 million.

According to the comptroller's office, the company spent more than $4.5 million on lobbying last year. That figure was based on data compiled by OpenSecrets.org, which showed Qualcomm spent more than $6 million on lobbying in both 2010 and 2011.

Qualcomm didn't initially respond Thursday to requests for comment.

DiNapoli said the lawsuit is a new tactic that holds promise for getting corporate transparency and accountability for shareholders. "It's just part of our continuing effort to have companies we invest in follow the best practices," he said.

The New York pension fund and other members of the Council of Institutional Investors sent letters to 430 companies in 2010 asking that they disclose political contributions made with corporate funds. In the past two years, the fund filed 27 shareholder resolutions asking for disclosures, reaching agreement with 10 companies, comptroller spokesman Eric Sumberg said.

The lawsuit says corporate political activity has risen sharply since the U.S. Supreme Court in 2010 removed restrictions on it. The suit also cites recent studies, including one from Strategic Management Journal in 2012 that indicates that spending in general "is negatively correlated with enterprise value." The abstract of that study said researchers looked at 943 companies from 1998 to 2008.

"We find that firms' political investments are negatively associated with market performance and cumulative political investments worsen both market and accounting performance," the abstract said

Firms that put former public officials on their boards also performed worse. Corporate political activity had a positive effect on market performance in regulated industries, it said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-01-03-Qualcomm-Political%20Spending/id-f026896547294d6eb0c33d52ffdbfcb6

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Rosewill Helios RK-9200 double backlights your keyboarding with two LEDs

Rosewill Helios RK9200 throws two LEDs behind its mechanical keys, double illuminates your keyboarding

It's nearly CES, which apparently means announcements of several mechanical gaming keyboards. Roccat kicked off the announcements earlier today with its Ryos, and tonight Rosewill's showing off its Helios RK-9200 -- a mechanical keyboard with not just one LED lighting up the board, but two. Imagine the possibilities! Both red and green LEDs are supported by the Helios, making this the perfect keyboard for Christmas celebrations. Of course, the family might not like all that clicking and clacking, but who are they to get in the way of your holiday gaming celebration?

Continue reading Rosewill Helios RK-9200 double backlights your keyboarding with two LEDs

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Source: http://www.engadget.com/2013/01/05/rosewill-helios-rk-9200/

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Saturday 5 January 2013

Dry winter adds to drought fears in Corn Belt

Saul Loeb / AFP - Getty Images

Corn stalks damaged by drought are seen on a farm near Oakland City, Ind., on Aug. 15.

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By Christine Stebbins, Reuters

CHICAGO -- The U.S. Corn Belt - the world's top grain region - is seeing another dry winter after the worst summer drought in half a century, reducing prospects for a bumper summer harvest that would help ease global food prices, crop and climate experts said.

"We are still concerned about getting the leftovers out of the way from the drought of 2012. At this time we would not anticipate a national corn yield above the trend," said Iowa State University climatologist Elwynn Taylor, who has studied crop production for decades. "Rather, we would expect a fourth consecutive year of below-trend crop, not as far below as in 2012 but still not up to par."

The 2012 drought locked two-thirds of the U.S. continental land mass in severe drought last summer, cutting production of the biggest crop, corn, by 27 percent from early season estimates.

The U.S. supplies more than half of world exports of corn, which is the top livestock feed for meat and dairy animals, the main feedstock for ethanol production, and the leading ingredient in dozens of food and industrial products from vegetable oil to sweeteners, paints and plastics. As such, its price is a key for food inflation and its supply outlook is closely watched by Federal Reserve policymakers, bankers, farm suppliers and food processors.


On Thursday, the government's weekly U.S. Drought Monitor said that 42.05 percent of the continental United States remained in severe to exceptional drought, down from 42.45 percent the previous week. Parts of the Corn Belt east of the Mississippi River and parts of the central Plains received snow over the last week, providing some much-needed moisture. But the snow did not offer much drought relief, with little improvement expected over the winter, according to the report.

Taylor and other crop specialists said continued lack of snow and rain was the biggest threat in the western Corn Belt - Minnesota and South Dakota south to Iowa, Nebraska, Missouri and Kansas. Those states produce about half the U.S. crop.

Taylor said in December it would take about 16 inches of precipitation by April 1 to recharge moisture in Corn Belt soils, up from the usual 12 inches that farmers look for over the winter.

Worst drought in decades hits Brazil's Northeast

The moisture is vital to spur adequate corn, soybean and spring wheat plant roots, which extend several feet down to tap into subsoil moisture. Persistent drought over more than a year in many areas meant plant roots drove down 8 or 9 feet last year in search of moisture, compared with the usual 5 feet.

"Most agricultural soils hold about 2 inches of water available to crops per foot of soil," Taylor said. "With most of the moisture gone that means it will take 16 inches of water soaking into the soil and in some places 18 to fully replenish it."

A long shot
Jim Angel, state climatologist in Illinois, said the state's conditions had improved slightly but have a long way to go before spring. Some areas of Illinois would need up to 21 inches of precipitation to catch up.

"The 2012 drought is not over yet. There are several areas of the state that are 8 to 12 inches below normal in rainfall, some places even more. You don't have to totally erase the deficits to be out of the drought but you have to come pretty close," Angel said. "In wintertime it's tough because we don't get that much precipitation. It's a long shot at this point."

Illinois saw its second hottest year on record in 2012, averaging 55.5 degrees, or 3.3 degrees above normal, and the 10th driest. The state's subsoil moisture is still rated 67 percent short to very short, according to the Illinois crop update issued this week.

Nebraska, the third largest corn producing state, has 77 percent of the state remaining in exceptional drought, according to the latest Drought Monitor.

Louisiana cemeteries sinking, washing away

"The concern is we just went through a 14-15 month stretch of incredibly dry weather in most locations in the state, excluding the southeast corner. For the vast majority of locations outside that area we were looking at 40 to 50 percent of annual precipitation that fell in 2012, and that does not include the exceptionally dry fall of 2011," said Al Dutcher, state climatologist for Nebraska.

To eliminate the soil moisture deficits over the next three months, Dutcher said central Nebraska needs 300 percent of normal precipitation while northeast and western Nebraska need 500 to 700 percent of normal precipitation this winter.

"One key issue for us since we are not getting a massive amount of moisture is to keep a protective snow layer across the northern and central Plains so we don't break dormancy as early as it did last year," Dutcher said. "Last year we were putting leaves on trees in early March, typically that doesn't happen until early April. That additional month of water use compounded the problem with the drought as we got into mid-summer."

Prayers for El Nino?
Scientists are hoping they will have a better indication by early February of the seasonal weather pattern, which depends on whether conditions turn to an El Nino or La Nina - global weather atmospheric anomalies based on the warming or cooling of an area of the southern Pacific Ocean that can dictate precipitation patterns in North America.

El Nino, a warming of Pacific waters, often leads to wetter weather in the U.S. Midwest. La Nina, a cooling of the waters, can have the opposite effect.

Climate experts say the El Nino/La Nina outlook is currently "neutral" based on data from the National Weather Service and other government forecasts.

Video: Drought conditions dry out Mississippi River

"We do not have any clear signal that's telling us whether it could be wetter or drier or near normal precipitation. That's the same for temperature," said John Eise, climate services program manager for the National Weather Service. "When you're looking out that far, going out a month or three months, it depends very strongly on whether we are in an El Nino or La Nina. Right now we are between the two."

The next El Nino-La Nina outlook from the U.S. Climate Prediction Center will be released Jan. 10.

Taylor said a return of La Nina, which the U.S. experienced in 2012, could be devastating: a return of abnormally high temperatures and diminished rains.

Video:?A promising sign for California?s water supply

"We can be concerned with this dryness but we could have the same setup as 2001, 2003, 2007 that followed major drought years in western Nebraska where it turned exceptionally wet in the spring, reduced irrigation demands. We still carried a high hydrological drought, but agriculturally we were at yield trend or above trend," Dutcher said.

For the moment, however, the worries remain. Freezing temperatures hitting much of the Midwest this week will prevent any moisture from permeating the soil.

"Even if we got normal precipitation through the winter that would not necessarily take care of the drought west of the Mississippi River. It's pretty tough now," Eise said.?

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Source: http://usnews.nbcnews.com/_news/2013/01/04/16355471-drought-still-grips-corn-belt-dry-winter-adds-to-farmers-fears?lite

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Eric Chessen's Autism Fitness PAC Profile for Occupational and ...

Eric Chessen's Autism Fitness PAC Profile for Occupational and Physical Therapists- Assessment and Workouts for individuals on the Autism SpectrumClick Image For Info!Eric Chessen takes you step by step using his easy to follow Manuals, Assessment Grids and Videos to better prepare you to understand your participants abilities and help you create outstanding fitness programs.

"No one in the world has ever created something so simple yet so effective for assessing an individual on the Autism Spectrum that wants to participate in a real fitness program. Eric Chessen has proven once again that he is definitely the Leading Authority in Autism Fitness. His Chessen Matrix is invaluable in understanding where your participant?s baseline for activity really is. Many of my clients with youth on the Spectrum rely on Eric?s unmatched ability." Rocco Castellano ? Emmy Award Winning Fitness Professional

"Eric Chessen is quite simply the very best professional in the world when it comes to fitness for the special needs child. I sit mesmerized each and every time we discuss this topic as his depth of knowledge on the topic is without equal. Perhaps larger and more importantly than that however, Eric is constantly on the lookout for ways to improve his understanding of exercise implementation, coaching and program design. I fully endorse Eric as the most trusted man in industry related to fitness and the special needs child." Brian Grasso ? Founder, International Youth Conditioning Association

"As an educator, I know that you can create a physical education program for your special needs students in only one day! The PAC Profile Assessment Tool Box is for students of all ages and teachers don?t need to be familiar with fitness in order to develop a fun and effective program. This is the only special needs fitness program available that assesses all three critical areas of development ? physical, behavioral and cognitive." Pat Wyman ? Founder, HowtoLearn.com? and Instructor, California State University ? East Bay

What will autism look like five, ten, or twenty years from now? How can Occupational Therapists, Physical Therapists, educators, and fitness professionals begin meeting tomorrow?s needs today? What are the best methods for ensuring optimal, lifelong health and well-being for individuals on the autism spectrum?

Almost a decade ago I began considering these questions. When I began working with teenagers on the autism spectrum developing fitness programs to suit their individual needs, I did not immediately realize that it would become my lifelong passion to bring fitness, health, and optimal life strategies to the ASD community. As a fitness professional and consultant, I knew that exercise was a gateway towards greater abilities in life. For the autism population, fitness can be used to create new opportunities and skills including self-awareness, self-esteem, self-initiative, and socialization. These are aspects of life that are far too important to go unaccounted for. Working with children, teens, and young adults on the spectrum in both individual and group situations, home and educational environments, I learned how valuable and remarkably effective phyiscal fitness was. I wanted to share what I?ve learned, and what I continue to learn, with parents, educators, and fitness professionals everywhere Read more?

Source: http://healthandfitness.fxvortex.com/2013/01/eric-chessens-autism-fitness-pac-profile-for-occupational-and-physical-therapists-assessment-and-workouts-for-individuals-on-the-autism-spectrum/

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Friday 4 January 2013

Pot Legal in Washington and Colorado?but not for Servicemembers

? January 3, 2013Posted in: Operations

Washington and Colorado have recently updated their laws on the use of marijuana, essentially decriminalizing use for civilians, however, the Navy reminds Sailors?it?s Zero Tolerance drug policy regulations remain unaffected:

The Zero Tolerance drug policy was implemented after a fatal crash of an EA-6B Prowler n board USS Nimitz in 1981, killing 14 crew members and injuring 45 others. Autopsies were performed and several members of the flight deck crew tested positive for marijuana. Following this discovery, then-President Ronald Reagan instituted a Zero Tolerance drug policy across all of the U.S. Armed Forces.? As a result regular, random urinalysis drug checks are conducted on all military personnel.

Read the entire article here.

Source: http://tpc.dodlive.mil/index.php/2013/01/03/pot-legal-in-washington-and-colorado-but-not-for-servicemembers/

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Beat Debt, Manage Money, Get Discplined | YMCA of Greater Erie, PA

Beginning on January 29, the County Y will offer Financial Peace University, a personal money-management class led by Dave Ramsey.? Through a 13-week series of DVDs and small group discussion, class participants will work together to beat debt, learn basic money-management skills and how to apply principles they are learning.? ?Get to Know You Sessions? will be held on Jan. 15 and Jan. 22 at 6 p.m.

The course is offered to County Y and community members beginning Jan. 29 at 6 p.m.? Cost for the 13-week course, which meets one time per week, is $99 and financial assistance is available.? Registration is required at www.daveramsey.com/fpu/home. ?If you?d like information about financial assistance, call the County Y at (814) 734-5700 and ask to speak to Mike Kern.

For more information about Financial Peace University, visit www.daveramsey.com or call the County Y at (814) 734-5700.

Download a complete press release.

Download event flyer.

Source: http://www.ymcaerie.org/2013/01/beat-debt-manage-money-get-discplined/

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Swiss bank to pay $57.8M in US tax evasion plea

(AP) ? A Swiss bank says it has agreed to pay $57.8 million to settle a court case in which it was charged with conspiring to help American clients hide more than $1.2 billion from the Internal Revenue Service.

Wegelin & Co. said Thursday that under the plea deal accepted by U.S. District Judge Jed Rakoff in New York City, the firm admits to violating American law by operating accounts for U.S. taxpayers between 2002 and 2010.

The bank was accused of helping at least 100 U.S. clients conceal huge sums of money from the federal tax collection agency in overseas accounts.

Wegelin says it agreed to pay $20 million restitution for lost taxes, a $22 million fine and $15.8 million for its estimated profits from the U.S. activities.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-01-03-Switzerland-US-Tax%20Evasion/id-5f6a009a3d2743568df76ebfed7d7d3f

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Rethinking bacterial persistence

Rethinking bacterial persistence [ Back to EurekAlert! ] Public release date: 3-Jan-2013
[ | E-mail | Share Share ]

Contact: Emmanuel Barraud
emmanuel.barraud@epfl.ch
41-796-283-642
Ecole Polytechnique Fdrale de Lausanne

Optofluidics allow for a new understanding of resistance to antibiotics

It's often difficult to completely eliminate a bacterial infection with antibiotics; part of the population usually manages to survive. We've known about this phenomenon for quite some time, dating back nearly to the discovery of penicillin. For more than 50 years, scientists have believed that the resistant bacteria were individuals that had stopped growing and dividing.

Up to now, in fact, it hasn't been possible to track the growth of cells before and after their exposure to antibiotics, which makes any analysis of the phenomenon quite imprecise. "Using microfluidics, we can now observe every bacterium individually, instead of having to count a population," says John McKinney, director of EPFL's Microbiology and Microsystems Laboratory (LMIC).

Active survivors

This new tool has revealed quite a few surprises. "We thought that surviving bacteria made up a fixed population that stopped dividing, but instead we found that some of them continued to divide and others died. The persistent population is thus very dynamic, and the cells that constitute it are constantly changing even though the total number of cells remains the same. Because they're dividing, the bacteria can mutate and thus develop resistance in the presence of the antibiotic," explains LMIC scientist Neeraj Dhar.

This point is extremely important. "We were able to eliminate a purely genetic explanation of the phenomenon," continues Dhar. In other words, "a population of genetically identical bacteria consists of individuals with widely varying behavior. Some of them can adapt to stressors that they have not previously encountered, thanks to the selection of persistent individuals. This could lead to a revision of the entire theory of adaptation," says McKinney.

Intermittent efficiency

The EPFL scientists were particularly interested in a relative of the tuberculosis bacterium. Their observations enabled them to formally challenge the argument that persistent bacteria are those that have stopped growing and dividing. "We were able to reveal the role of an enzyme whose presence is necessary in order for the antibiotic to work, and show that the bacilli produced this enzyme in a pulsatile and random manner," explains Dhar. "Our measurements showed that bacterial death correlated more closely with the expression of this enzyme than with their growth factor." The research is being published this week in Science magazine.

These conclusions could mark the beginning of a new theory of bacterial resistance, or perhaps even introduce a new view of how such resistance evolves. Further research is being done using other microorganisms, such as tuberculosis and E. coli bacteria. The persistence of some cancer cells to treatment could also be studied in a different manner. "It's a new approach for trying to figure out why some infections are so difficult to eliminate. The techniques we've developed for this study are now also being used to develop new antibiotics, in collaboration with pharmaceutical companies," says McKinney, adding that "it is the microengineering expertise at EPFL that has enabled us to create these innovative tools and open up new avenues for investigation."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Rethinking bacterial persistence [ Back to EurekAlert! ] Public release date: 3-Jan-2013
[ | E-mail | Share Share ]

Contact: Emmanuel Barraud
emmanuel.barraud@epfl.ch
41-796-283-642
Ecole Polytechnique Fdrale de Lausanne

Optofluidics allow for a new understanding of resistance to antibiotics

It's often difficult to completely eliminate a bacterial infection with antibiotics; part of the population usually manages to survive. We've known about this phenomenon for quite some time, dating back nearly to the discovery of penicillin. For more than 50 years, scientists have believed that the resistant bacteria were individuals that had stopped growing and dividing.

Up to now, in fact, it hasn't been possible to track the growth of cells before and after their exposure to antibiotics, which makes any analysis of the phenomenon quite imprecise. "Using microfluidics, we can now observe every bacterium individually, instead of having to count a population," says John McKinney, director of EPFL's Microbiology and Microsystems Laboratory (LMIC).

Active survivors

This new tool has revealed quite a few surprises. "We thought that surviving bacteria made up a fixed population that stopped dividing, but instead we found that some of them continued to divide and others died. The persistent population is thus very dynamic, and the cells that constitute it are constantly changing even though the total number of cells remains the same. Because they're dividing, the bacteria can mutate and thus develop resistance in the presence of the antibiotic," explains LMIC scientist Neeraj Dhar.

This point is extremely important. "We were able to eliminate a purely genetic explanation of the phenomenon," continues Dhar. In other words, "a population of genetically identical bacteria consists of individuals with widely varying behavior. Some of them can adapt to stressors that they have not previously encountered, thanks to the selection of persistent individuals. This could lead to a revision of the entire theory of adaptation," says McKinney.

Intermittent efficiency

The EPFL scientists were particularly interested in a relative of the tuberculosis bacterium. Their observations enabled them to formally challenge the argument that persistent bacteria are those that have stopped growing and dividing. "We were able to reveal the role of an enzyme whose presence is necessary in order for the antibiotic to work, and show that the bacilli produced this enzyme in a pulsatile and random manner," explains Dhar. "Our measurements showed that bacterial death correlated more closely with the expression of this enzyme than with their growth factor." The research is being published this week in Science magazine.

These conclusions could mark the beginning of a new theory of bacterial resistance, or perhaps even introduce a new view of how such resistance evolves. Further research is being done using other microorganisms, such as tuberculosis and E. coli bacteria. The persistence of some cancer cells to treatment could also be studied in a different manner. "It's a new approach for trying to figure out why some infections are so difficult to eliminate. The techniques we've developed for this study are now also being used to develop new antibiotics, in collaboration with pharmaceutical companies," says McKinney, adding that "it is the microengineering expertise at EPFL that has enabled us to create these innovative tools and open up new avenues for investigation."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-01/epfd-rbp123112.php

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Turkish Registrar Enabled Phishers to Spoof ... - Krebs on Security

Google and Microsoft today began warning users about active phishing attacks against Google?s online properties. The two companies said the attacks resulted from a fraudulent digital certificate that was mistakenly issued by a domain registrar run by a Turkish domain registrar.

In a blog post published today, Google said that on Dec. 24, 2012, its Chrome Web browser detected and blocked an unauthorized digital certificate for the ?*.google.com? domain.

?We investigated immediately and found the certificate was issued by an?intermediate certificate authority?(CA) linking back to TURKTRUST, a Turkish certificate authority,? wrote?Adam Langley, a Google software engineer. ?Intermediate CA certificates carry the full authority of the CA, so anyone who has one can use it to create a certificate for any website they wish to impersonate.?

Langley said that Google responded by Chrome on December 25 to block that intermediate CA, and then alerted TURKTRUST and other browser vendors. ?TURKTRUST told us that based on our information, they discovered that in August 2011 they had mistakenly issued two intermediate CA certificates to organizations that should have instead received regular SSL certificates. On December 26, we pushed another Chrome metadata update to block the second mistaken CA certificate and informed the other browser vendors.?

Separately, Microsoft has issued an advisory with a bit more detail, saying it is aware of active attacks using one of the fraudulent digital certificates issued by TURKTRUST Inc.

?This fraudulent certificate could be used to spoof content, perform phishing attacks, or perform man-in-the-middle attacks. This issue affects all supported releases of Microsoft Windows,? the software giant warned.

According to Microsoft, TURKTRUST Inc. incorrectly created two subsidiary CAs (*.EGO.GOV.TR and e-islem.kktcmerkezbankasi.org). The *.EGO.GOV.TR subsidiary CA was then used to issue a fraudulent digital certificate to *.google.com. This fraudulent certificate could be used to spoof content, perform phishing attacks, or perform man-in-the-middle attacks against several Google web properties.? [link added]

It?s not clear yet whether this was an attack against Turkish residents, or if the targets were more widespread geographically. The domain that Microsoft mentioned in its advisory ??kktcmerkezbankasi.org ??is not resolving at the moment. But according to a screen shot of the domain?s home page taken by Domaintools.com on March 14, 2012 (see image above), the site represented itself as the Central Bank of the Turkish Republic of Northern Cyprus (TRNC), a financial institution established in Northern Cyprus in 1983.

In any case, compromises like this one can lead to colossal security failures. An attacker with certificate authority signing ability can sign certificates for virtually any domain.?The TURKTRUST incident harkens back to another similar compromise that happened around the same timeframe. In September 2011, Dutch certificate authority Diginotar learned that a security breach at the firm had resulted in the fraudulent issuing of certificates. A follow-up investigation ?suggested that the attacker who penetrated the Dutch CA DigiNotar last year had complete control of all eight of the company?s certificate-issuing servers during the operation and he may also have issued some rogue certificates that have not yet been identified. Diginotar later declared bankruptcy.

Microsoft has pushed out an update that addresses this weakness and removes the fraudulent certificates from the list of trusted certs in Windows. According to Microsoft, the update should be automatically deployed to users on Windows 8, Windows RT, Windows Server 2012 and devices running Windows Phone 8.?An automatic updater of revoked certificates is available for Windows Vista, Windows Server 2008, Windows 7, and Windows Server 2008 R2, from?this link.?Windows XP and Windows Server 2003 customers can grab the update via Microsoft Update (it?s not immediately clear from Microsoft?s advisory whether users of other Windows versions can obtain the update from Microsoft Update as well).

Update, 3:57 p.m. ET:A previous version of this story incorrectly named TURKTRUST as an institution run by the Turkish government. The above copy has been corrected.

Update, 4:16 p.m. ET:?Firefox browser maker Mozilla?just published a blog post noting that it, too, was revoking the fraudulent certs.

Tags: .ego.gov.tr, Central Bank of the Turkish Republic of Northern Cyprus, google, Google.com, islem.kktcmerkezbankasi.org, KB2677070, KB2798897, microsoft, TURKTRUST, TURKTRUST INC.

Source: http://krebsonsecurity.com/2013/01/turkish-registrar-enabled-phishers-to-spoof-google/

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Asia stocks eke out gains on China hopes, oil eases

HONG KONG (Reuters) - Most Asian stock markets edged higher on Thursday on hopes of a steady economic revival in China, although oil gave back part of the previous session's strong gains as investors took some money off the table and braced for more U.S. budget battles.

The MSCI Asia Pacific ex-Japan index of stocks <.miapj0000pus> rose 0.2 percent following Wednesday's 2 percent jump on relief that U.S. politicians had averted the "fiscal cliff".

Data from China showing the services sector expanded in December continued to underpin expectations of an economic recovery that has helped spur a strong rally in Hong Kong-listed Chinese shares <.hsce> over the past month.

The China Enterprises index <.hsce> which rallied more than 4 percent in the previous session eased 0.2 percent. Onshore Chinese markets will resume trading on Friday.

"China looks like it's improving at the margin and the market has momentum that could last for at least a few months," said Christian Keilland, head of trading at BTIG in Hong Kong.

"Investors seem to have accepted that reforms are underway but they're going to happen at a slower pace."

Australian stocks <.axjo> rose 0.7 percent to their highest in more than 19 months, with mining giants Rio Tinto up 2.4 percent and BHP Billiton up 0.8 percent, among the top gainers on the benchmark S&P ASX/200 index. <.axjo/>

South Korea's Kospi <.ks11> underperformed the region, falling 0.4 percent as automakers and other exporters slumped on a stronger Korean won, which hit a 16-month high against the dollar overnight.

In other currency markets, the Japanese yen bounced after hitting a 29-month low versus the dollar earlier in the day but analysts warned that any strength is likely to be short-lived.

"Technically dollar/yen looks somewhat overbought here. It's gone a long way in a very short time," said Callum Henderson, global head of FX research for Standard Chartered Bank in Singapore, adding that the dollar could see some consolidation in the near term before heading higher.

The euro which in overnight trading was close to a 8-1/2 month high against the dollar, slipped 0.1 percent.

The U.S. dollar rose 0.2 percent <.dxy> against a basket of major currencies.

President Barack Obama and congressional Republicans face even bigger budget battles in the next two months after a hard-fought deal averted the fiscal cliff of automatic tightening that threatened to push the U.S. into recession.

Strength in the dollar and profit-taking pushed oil prices lower with Brent crude slipping 0.3 percent and U.S. crude futures down 19 cents to $92.93.

"After the initial excitement, reality sets in," said Victor Shum, oil consultant at IHS Purvin & Gertz. "There will be other negotiations and the deal is a compromise."

(Reporting by Vikram Subhedar; Editing by Kim Coghill and Eric Meijer)

Source: http://news.yahoo.com/asia-stocks-oil-breather-rally-002513787--finance.html

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